Droperidol

CHEMBL1108 Phase 4 Aprobado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

379.4 g/mol

LogP

3.5

Phase

4

A butyrophenone antipsychotic and antiemetic used to prevent nausea and vomiting during surgery and anesthesia, and to treat acute agitation. It blocks dopamine receptors in the brain.

Peso molecular

379,4000 g/mol

LogP

3,50

TPSA

52,70 Å²

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Cáncer de mama Cáncer de pulmón de células no pequeñas Dolor crónico Esquizofrenia Manejo del dolor Migraña Obesidad

Mecanismo de acción

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal …

Estructura 2D

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SMILES

O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1

InChI

InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)

Molecular Formula

C22H22FN3O2

HBD / HBA

1 / 4

Enlaces Rotables

6

Átomos Pesados

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

A butyrophenone antipsychotic and antiemetic used to prevent nausea and vomiting during surgery and anesthesia, and to treat acute agitation. It blocks dopamine receptors in the brain.

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.

Yes, Droperidol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1108. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3168. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Estructura

Datos Rápidos

Fórmula: C22H22FN3O2
Sinónimos: 1

Enlaces externos

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Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.