Futibatinib
This oral medication selectively and irreversibly inhibits FGFR1-4, receptors that drive the growth of certain cancers when mutated or overactive. It is used to treat cholangiocarcinoma with FGFR2 gene rearrangements and is being studied in bladder and breast cancers with FGFR alterations.
Peso molecular
418,4000 g/mol
LogP
2,00
TPSA
108,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
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SMILES
C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1
InChI
InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1
Molecular Formula
C22H22N6O3
HBD / HBA
1 / 7
Enlaces Rotables
6
Átomos Pesados
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This oral medication selectively and irreversibly inhibits FGFR1-4, receptors that drive the growth of certain cancers when mutated or overactive. It is used to treat cholangiocarcinoma with FGFR2 gene rearrangements and is being studied in bladder and breast cancers with FGFR alterations.
Yes, Futibatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3701238. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 71621331. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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