Granisetron
A selective serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin receptors in the gut and brain that trigger the vomiting reflex when activated by cytotoxic treatments. It is available in oral, intravenous, and transdermal patch formulations.
Peso molecular
312,4000 g/mol
LogP
2,80
TPSA
50,20 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2
InChI
InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)
Molecular Formula
C18H24N4O
HBD / HBA
1 / 3
Enlaces Rotables
2
Átomos Pesados
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A selective serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin receptors in the gut and brain that trigger the vomiting reflex when activated by cytotoxic treatments. It is available in oral, intravenous, and transdermal patch formulations.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Granisetron is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL289469. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5284566. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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