Histamine Dihydrochloride
This is the dihydrochloride salt form of histamine, used in an approved combination therapy with interleukin-2 for the treatment of acute myeloid leukemia in remission. It works by protecting natural killer cells and T-cells from reactive oxygen species produced by monocytes, thereby enhancing the anti-cancer immune response. The salt form is used for pharmaceutical stability.
Peso molecular
184,0600 g/mol
TPSA
54,70 Ų
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cl.Cl.NCCc1c[nH]cn1
InChI
InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
Molecular Formula
C5H11Cl2N3
HBD / HBA
4 / 2
Enlaces Rotables
2
Átomos Pesados
10
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This is the dihydrochloride salt form of histamine, used in an approved combination therapy with interleukin-2 for the treatment of acute myeloid leukemia in remission. It works by protecting natural killer cells and T-cells from reactive oxygen species produced by monocytes, thereby enhancing the anti-cancer immune response. The salt form is used for pharmaceutical stability.
Yes, Histamine Dihydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1533310. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5818. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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