Hydroxyzine Hydrochloride
This hydrochloride salt of hydroxyzine is the oral tablet and syrup form used to relieve anxiety, allergic itching, and tension. It has sedating effects through antihistamine and anticholinergic actions, making it useful for short-term anxiety management and preoperative sedation. It is considered non-habit-forming compared to many other anxiolytics.
Peso molecular
447,8000 g/mol
TPSA
35,90 Ų
Áreas terapéuticas
Mecanismo de acción
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cl.Cl.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
InChI
InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
Molecular Formula
C21H29Cl3N2O2
HBD / HBA
3 / 4
Enlaces Rotables
8
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This hydrochloride salt of hydroxyzine is the oral tablet and syrup form used to relieve anxiety, allergic itching, and tension. It has sedating effects through antihistamine and anticholinergic actions, making it useful for short-term anxiety management and preoperative sedation. It is considered non-habit-forming compared to many other anxiolytics.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Hydroxyzine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3186993. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 91513. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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