Imatinib Mesylate
This is the mesylate salt of imatinib, the first approved tyrosine kinase inhibitor, used to treat chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). By blocking the BCR-ABL oncoprotein and other kinases (c-Kit, PDGFR), it stops cancer cell proliferation. The mesylate salt form provides good oral bioavailability.
Peso molecular
589,7000 g/mol
TPSA
149,00 Ų
Áreas terapéuticas
Mecanismo de acción
Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.
Estructura 2D
Cite this structure
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SMILES
CS(=O)(=O)O.Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
InChI
InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
Molecular Formula
C30H35N7O4S
HBD / HBA
3 / 10
Enlaces Rotables
7
Átomos Pesados
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This is the mesylate salt of imatinib, the first approved tyrosine kinase inhibitor, used to treat chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). By blocking the BCR-ABL oncoprotein and other kinases (c-Kit, PDGFR), it stops cancer cell proliferation. The mesylate salt form provides good oral bioavailability.
Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.
Yes, Imatinib Mesylate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1642. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 123596. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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