Imatinib
This oral targeted cancer therapy works by inhibiting specific tyrosine kinase enzymes, particularly BCR-ABL, the abnormal protein produced by the Philadelphia chromosome in chronic myeloid leukemia (CML). It was a breakthrough in cancer treatment and is also used for gastrointestinal stromal tumors (GISTs) and other cancers driven by specific kinase mutations. It transformed CML from a frequently fatal disease to one often managed long-term.
Peso molecular
493,6030 g/mol
LogP
3,50
TPSA
86,30 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Clases de fármacos
Mecanismo de acción
Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1
InChI
InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
Molecular Formula
C29H31N7O
HBD / HBA
2 / 7
Enlaces Rotables
7
Átomos Pesados
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This oral targeted cancer therapy works by inhibiting specific tyrosine kinase enzymes, particularly BCR-ABL, the abnormal protein produced by the Philadelphia chromosome in chronic myeloid leukemia (CML). It was a breakthrough in cancer treatment and is also used for gastrointestinal stromal tumors (GISTs) and other cancers driven by specific kinase mutations. It transformed CML from a frequently fatal disease to one often managed long-term.
Selective inhibitor of BCR-ABL, c-Kit, and PDGFR tyrosine kinases.
Key pharmacokinetic parameters for Imatinib: Half-life: 18 hours.
Yes, Imatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL941. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5291. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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