Imidapril
This ACE inhibitor is used to treat hypertension (high blood pressure) and heart failure by blocking the enzyme that produces angiotensin II, a potent blood vessel constrictor. By reducing angiotensin II levels, it causes blood vessels to relax and reduces the workload on the heart. It may also slow the progression of kidney disease in diabetic patients.
Peso molecular
405,4000 g/mol
LogP
-0,70
TPSA
116,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers blood pressure.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1C(=O)N(C)C[C@H]1C(=O)O
InChI
InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1
Molecular Formula
C20H27N3O6
HBD / HBA
2 / 7
Enlaces Rotables
10
Átomos Pesados
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This ACE inhibitor is used to treat hypertension (high blood pressure) and heart failure by blocking the enzyme that produces angiotensin II, a potent blood vessel constrictor. By reducing angiotensin II levels, it causes blood vessels to relax and reduces the workload on the heart. It may also slow the progression of kidney disease in diabetic patients.
Inhibits angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This reduces peripheral vascular resistance, decreases aldosterone secretion, and lowers blood pressure.
Yes, Imidapril is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL317094. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5464343. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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