Indacaterol Maleate
This maleate salt of indacaterol is the formulation used in several approved once-daily inhaled products for COPD management. It provides sustained bronchodilation by stimulating beta-2 adrenergic receptors in the lungs, reducing airflow obstruction. The maleate salt offers good chemical stability in dry powder inhaler formulations.
Peso molecular
508,6000 g/mol
TPSA
156,00 Ų
Áreas terapéuticas
Mecanismo de acción
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Estructura 2D
Cite this structure
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SMILES
CCc1cc2c(cc1CC)CC(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C2.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C24H28N2O3.C4H4O4/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24;5-3(6)1-2-4(7)8/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29);1-2H,(H,5,6)(H,7,8)/b;2-1-/t22-;/m0./s1
Molecular Formula
C28H32N2O7
HBD / HBA
6 / 8
Enlaces Rotables
8
Átomos Pesados
37
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This maleate salt of indacaterol is the formulation used in several approved once-daily inhaled products for COPD management. It provides sustained bronchodilation by stimulating beta-2 adrenergic receptors in the lungs, reducing airflow obstruction. The maleate salt offers good chemical stability in dry powder inhaler formulations.
Activates beta-2 adrenergic receptors on bronchial smooth muscle, stimulating adenylyl cyclase and increasing intracellular cAMP. This relaxes airway smooth muscle and produces bronchodilation.
Yes, Indacaterol Maleate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1789842. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9827599. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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