Indomethacin
This potent nonsteroidal anti-inflammatory drug (NSAID) is used to treat moderate-to-severe pain and inflammation in conditions such as arthritis, gout, bursitis, and tendinitis. It works by inhibiting cyclooxygenase (COX) enzymes that produce prostaglandins. In newborns, intravenous indomethacin is used to close a patent ductus arteriosus.
Peso molecular
357,8000 g/mol
LogP
4,30
TPSA
68,50 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Estructura 2D
Cite this structure
Embed this structure
SMILES
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1
InChI
InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
Molecular Formula
C19H16ClNO4
HBD / HBA
1 / 4
Enlaces Rotables
4
Átomos Pesados
25
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This potent nonsteroidal anti-inflammatory drug (NSAID) is used to treat moderate-to-severe pain and inflammation in conditions such as arthritis, gout, bursitis, and tendinitis. It works by inhibiting cyclooxygenase (COX) enzymes that produce prostaglandins. In newborns, intravenous indomethacin is used to close a patent ductus arteriosus.
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.
Yes, Indomethacin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3715. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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