Ipragliflozin
This SGLT2 inhibitor works by blocking a kidney protein that reabsorbs glucose, causing excess sugar to be excreted in the urine and thereby lowering blood sugar levels in people with type 2 diabetes. It also promotes modest weight loss and blood pressure reduction.
Peso molecular
404,5000 g/mol
LogP
2,50
TPSA
118,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubule, reducing glucose reabsorption and promoting urinary glucose excretion. This lowers blood glucose levels independently of insulin secretion.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubule, reducing glucose reabsorption and promoting urinary glucose excretion. This lowers blood glucose levels independently of insulin secretion.
Estructura 2D
Cite this structure
Embed this structure
SMILES
OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C21H21FO5S/c22-15-6-5-12(21-20(26)19(25)18(24)16(10-23)27-21)7-13(15)9-14-8-11-3-1-2-4-17(11)28-14/h1-8,16,18-21,23-26H,9-10H2/t16-,18-,19+,20-,21+/m1/s1
Molecular Formula
C21H21FO5S
HBD / HBA
4 / 7
Enlaces Rotables
4
Átomos Pesados
28
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This SGLT2 inhibitor works by blocking a kidney protein that reabsorbs glucose, causing excess sugar to be excreted in the urine and thereby lowering blood sugar levels in people with type 2 diabetes. It also promotes modest weight loss and blood pressure reduction.
Selectively inhibits sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubule, reducing glucose reabsorption and promoting urinary glucose excretion. This lowers blood glucose levels independently of insulin secretion.
Yes, Ipragliflozin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2018096. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10453870. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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