Lenacapavir
A first-in-class HIV-1 capsid inhibitor used to treat multidrug-resistant HIV infection in combination with other antiretrovirals. It works at multiple stages of the viral life cycle by disrupting the protein shell that protects HIV's genetic material.
Peso molecular
968,3000 g/mol
LogP
6,40
TPSA
175,00 Ų
Regla de cinco de Lipinski
No cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CC(C)(C#Cc1ccc(-c2ccc(Cl)c3c(NS(C)(=O)=O)nn(CC(F)(F)F)c23)c([C@H](Cc2cc(F)cc(F)c2)NC(=O)Cn2nc(C(F)(F)F)c3c2C(F)(F)[C@@H]2C[C@H]32)n1)S(C)(=O)=O
InChI
InChI=1S/C39H32ClF10N7O5S2/c1-36(2,63(3,59)60)10-9-21-5-6-22(23-7-8-26(40)30-32(23)57(17-37(43,44)45)54-35(30)55-64(4,61)62)31(51-21)27(13-18-11-19(41)14-20(42)12-18)52-28(58)16-56-34-29(33(53-56)39(48,49)50)24-15-25(24)38(34,46)47/h5-8,11-12,14,24-25,27H,13,15-17H2,1-4H3,(H,52,58)(H,54,55)/t24-,25+,27-/m0/s1
Molecular Formula
C39H32ClF10N7O5S2
HBD / HBA
2 / 19
Enlaces Rotables
13
Átomos Pesados
64
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A first-in-class HIV-1 capsid inhibitor used to treat multidrug-resistant HIV infection in combination with other antiretrovirals. It works at multiple stages of the viral life cycle by disrupting the protein shell that protects HIV's genetic material.
Yes, Lenacapavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4594438. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 133082658. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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