Leucovorin

CHEMBL1679 Phase 4 Aprobado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

473.4 g/mol

LogP

-1.2

Phase

4

A form of folate (folinic acid) used to protect normal cells during high-dose methotrexate chemotherapy and to enhance the effectiveness of fluorouracil in colorectal and other cancers. It rescues cells from the toxic effects of methotrexate.

Peso molecular

473,4000 g/mol

LogP

-1,20

TPSA

216,00 Å²

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Anestesiología Artritis reumatoide Asma Cáncer colorrectal Cáncer de mama Cáncer de ovario Cáncer de páncreas Cáncer de próstata Cáncer de pulmón de células no pequeñas Cáncer de tiroides Cáncer de vejiga Degeneración macular relacionada con la edad Dermatitis atópica Dermatología Diabetes tipo 2 Dolor crónico Endocrinología Endometriosis Enfermedad cardiovascular Enfermedad de Alzheimer Enfermedad del hígado graso no alcohólico Enfermedad de Parkinson Enfermedad infecciosa Enfermedad inflamatoria intestinal Enfermedad por reflujo gastroesofágico Enfermedad pulmonar obstructiva crónica Enfermedad renal crónica Enfermedad respiratoria Epilepsia Esclerosis múltiple Esquizofrenia Fibrilación auricular Gastroenterología Glaucoma Gota Hematología Hepatitis C Hepatología Hiperlipidemia Hiperplasia prostática benigna Hipertensión Ictus Inmunología Insomnio Insuficiencia cardíaca Leucemia Linfoma Lupus eritematoso sistémico Malaria Manejo del dolor Medicina de trasplantes Melanoma Migraña Nefrología Neurología Obesidad Obstetricia y ginecología Oftalmología Oncología Osteoporosis Psiquiatría Psoriasis Reumatología Trastorno bipolar Trastorno de ansiedad generalizada Trastorno depresivo mayor Trombosis venosa profunda / Embolia pulmonar Tuberculosis Urología VIH/sida

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

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SMILES

Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2C=O

InChI

InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

Molecular Formula

C20H23N7O7

HBD / HBA

7 / 10

Enlaces Rotables

9

Átomos Pesados

34

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

A form of folate (folinic acid) used to protect normal cells during high-dose methotrexate chemotherapy and to enhance the effectiveness of fluorouracil in colorectal and other cancers. It rescues cells from the toxic effects of methotrexate.

Yes, Leucovorin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1679. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 135403648. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Estructura

Datos Rápidos

Fórmula: C20H23N7O7
Sinónimos: 6

Enlaces externos

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Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.