Levonordefrin
A sympathomimetic vasoconstrictor used in combination with local anesthetics in dental procedures to prolong anesthesia and reduce bleeding. It narrows blood vessels at the injection site to slow the absorption of the anesthetic.
Peso molecular
183,2000 g/mol
LogP
-0,80
TPSA
86,70 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Estructura 2D
Cite this structure
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SMILES
C[C@H](N)[C@H](O)c1ccc(O)c(O)c1
InChI
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
Molecular Formula
C9H13NO3
HBD / HBA
4 / 4
Enlaces Rotables
2
Átomos Pesados
13
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A sympathomimetic vasoconstrictor used in combination with local anesthetics in dental procedures to prolong anesthesia and reduce bleeding. It narrows blood vessels at the injection site to slow the absorption of the anesthetic.
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.
Yes, Levonordefrin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL677. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 164739. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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