Macitentan
An endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH) by blocking the action of endothelin, a substance that causes blood vessels in the lungs to narrow. It helps improve exercise capacity and slow disease progression.
Peso molecular
588,3000 g/mol
LogP
3,70
TPSA
137,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1
InChI
InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
Molecular Formula
C19H20Br2N6O4S
HBD / HBA
2 / 10
Enlaces Rotables
11
Átomos Pesados
32
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
An endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH) by blocking the action of endothelin, a substance that causes blood vessels in the lungs to narrow. It helps improve exercise capacity and slow disease progression.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Macitentan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2103873. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 16004692. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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