Melphalan Flufenamide Hydrochloride
A hydrochloride salt form of melphalan flufenamide, a prodrug alkylating chemotherapy used in combination with dexamethasone for heavily pretreated relapsed or refractory multiple myeloma.
Peso molecular
534,9000 g/mol
TPSA
84,70 Ų
Mecanismo de acción
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CCOC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](N)Cc1ccc(N(CCCl)CCCl)cc1.Cl
InChI
InChI=1S/C24H30Cl2FN3O3.ClH/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26;/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31);1H/t21-,22-;/m0./s1
Molecular Formula
C24H31Cl3FN3O3
HBD / HBA
3 / 6
Enlaces Rotables
14
Átomos Pesados
34
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A hydrochloride salt form of melphalan flufenamide, a prodrug alkylating chemotherapy used in combination with dexamethasone for heavily pretreated relapsed or refractory multiple myeloma.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Melphalan Flufenamide Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4297403. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 70675838. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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