Metolazone
This diuretic medication helps the kidneys remove excess salt and water from the body, lowering blood pressure and reducing fluid buildup. It is used in the management of heart failure and chronic kidney disease.
Peso molecular
365,8000 g/mol
LogP
4,10
TPSA
101,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cc1ccccc1N1C(=O)c2cc(S(N)(=O)=O)c(Cl)cc2NC1C
InChI
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
Molecular Formula
C16H16ClN3O3S
HBD / HBA
2 / 5
Enlaces Rotables
2
Átomos Pesados
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This diuretic medication helps the kidneys remove excess salt and water from the body, lowering blood pressure and reducing fluid buildup. It is used in the management of heart failure and chronic kidney disease.
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.
Yes, Metolazone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL878. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4170. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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