Momelotinib Dihydrochloride

CHEMBL2219411 Phase 4 Aprobado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

487.4 g/mol

LogP

—

Phase

4

A dihydrochloride salt form of momelotinib, a JAK1/JAK2 inhibitor used to treat myelofibrosis, a bone marrow disorder causing scarring and abnormal blood cell production. It reduces spleen size, improves anemia, and relieves constitutional symptoms such as fatigue and night sweats.

Peso molecular

487,4000 g/mol

TPSA

103,00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

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SMILES

Cl.Cl.N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1

InChI

InChI=1S/C23H22N6O2.2ClH/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29;;/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28);2*1H

Molecular Formula

C23H24Cl2N6O2

HBD / HBA

4 / 7

Enlaces Rotables

6

Átomos Pesados

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

A dihydrochloride salt form of momelotinib, a JAK1/JAK2 inhibitor used to treat myelofibrosis, a bone marrow disorder causing scarring and abnormal blood cell production. It reduces spleen size, improves anemia, and relieves constitutional symptoms such as fatigue and night sweats.

Yes, Momelotinib Dihydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2219411. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 57345482. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Momelotinib Dihydrochloride en PillFYI

Estructura

Datos Rápidos

Fórmula: C23H24Cl2N6O2

Enlaces externos

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Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.