Nalfurafine
A kappa-opioid receptor agonist approved in Japan to treat severe chronic itch (pruritus) in patients on hemodialysis and those with liver disease. Unlike mu-opioid agonists, it targets kappa receptors to relieve itch without the risk of euphoria or dependence.
Peso molecular
476,6000 g/mol
LogP
1,00
TPSA
86,40 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Mecanismo de acción
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Estructura 2D
Cite this structure
Embed this structure
SMILES
CN(C(=O)/C=C/c1ccoc1)[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5
InChI
InChI=1S/C28H32N2O5/c1-29(23(32)7-4-18-9-13-34-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)35-25)11-12-30(22)15-17-2-3-17/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3/b7-4+/t20-,22-,26+,27+,28-/m1/s1
Molecular Formula
C28H32N2O5
HBD / HBA
2 / 6
Enlaces Rotables
5
Átomos Pesados
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
A kappa-opioid receptor agonist approved in Japan to treat severe chronic itch (pruritus) in patients on hemodialysis and those with liver disease. Unlike mu-opioid agonists, it targets kappa receptors to relieve itch without the risk of euphoria or dependence.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Nalfurafine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL267495. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6445230. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="nalfurafine"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/nalfurafine/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/nalfurafine/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/nalfurafine/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="nalfurafine"></drugfyi-drug>