Nitroxoline
An 8-hydroxyquinoline antibiotic used in several countries to treat urinary tract infections, particularly those caused by E. coli and Staphylococcus. It works by chelating metal ions essential for bacterial enzyme function and DNA replication.
Peso molecular
190,1600 g/mol
LogP
2,10
TPSA
78,90 Ų
Regla de cinco de Lipinski
Cumple
Mecanismo de acción
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Estructura 2D
Cite this structure
Embed this structure
SMILES
O=[N+]([O-])c1ccc(O)c2ncccc12
InChI
InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
Molecular Formula
C9H6N2O3
HBD / HBA
1 / 4
Enlaces Rotables
0
Átomos Pesados
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
An 8-hydroxyquinoline antibiotic used in several countries to treat urinary tract infections, particularly those caused by E. coli and Staphylococcus. It works by chelating metal ions essential for bacterial enzyme function and DNA replication.
Forms stable, water-soluble chelate complexes with specific metal ions, facilitating their excretion from the body through the kidneys. This reduces toxic metal burden in affected tissues.
Yes, Nitroxoline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1454910. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 19910. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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