Perphenazine

CHEMBL567 Phase 4 Aprobado Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

404.0 g/mol

LogP

4.2

Phase

4

Perphenazine is a typical antipsychotic belonging to the phenothiazine class that exerts its effects primarily by blocking dopamine D2 receptors in the mesolimbic and mesocortical pathways. It is used in the treatment of schizophrenia, bipolar disorder, and severe anxiety, and also possesses antiemetic properties due to its action on dopamine receptors in the chemoreceptor trigger zone.

Peso molecular

404,0000 g/mol

LogP

4,20

TPSA

55,30 Å²

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Esquizofrenia Ictus Obesidad Trastorno bipolar Trastorno de ansiedad generalizada

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Estructura 2D

SVG PNG

Cite this structure

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SMILES

OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1

InChI

InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

Molecular Formula

C21H26ClN3OS

HBD / HBA

1 / 5

Enlaces Rotables

6

Átomos Pesados

27

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

Perphenazine is a typical antipsychotic belonging to the phenothiazine class that exerts its effects primarily by blocking dopamine D2 receptors in the mesolimbic and mesocortical pathways. It is used in the treatment of schizophrenia, bipolar disorder, and severe anxiety, and also possesses antiemetic properties due to its action on dopamine receptors in the chemoreceptor trigger zone.

Yes, Perphenazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL567. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 4748. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Perphenazine en PillFYI

Estructura

Datos Rápidos

Fórmula: C21H26ClN3OS

Enlaces externos

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Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.