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Podophyllum Resin

CHEMBL2108775 Phase 4 Aprobado Unknown
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1693.6 g/mol
LogP
—
Phase
4

Podophyllum resin is a complex mixture of cytotoxic compounds extracted from the Podophyllum plant species, with podophyllotoxin as the principal active constituent, that exerts antimitotic effects by binding to tubulin and inhibiting microtubule polymerization, arresting cell division in metaphase. It has been used topically as a caustic agent for the treatment of condylomata acuminata and other warts.

Peso molecular

1693,6000 g/mol

TPSA

433,00 Ų

Mecanismo de acción

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

SMILES

COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O.COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O.COC1=CC(=CC(=C1OC)OC)C2C(C(C(C3=CC4=C(C=C23)OCO4)O)CO)C(=O)O.COC1=CC(=CC(=C1OC)OC)C2C(C(C(C3=CC4=C(C=C23)OCO4)O)CO)C(=O)O

InChI

InChI=1S/2C22H24O9.2C22H22O8/c2*1-27-16-4-10(5-17(28-2)21(16)29-3)18-11-6-14-15(31-9-30-14)7-12(11)20(24)13(8-23)19(18)22(25)26;2*1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h2*4-7,13,18-20,23-24H,8-9H2,1-3H3,(H,25,26);2*4-7,13,18-20,23H,8-9H2,1-3H3

Molecular Formula

C88H92O34

HBD / HBA

8 / 34

Enlaces Rotables

20

Átomos Pesados

122

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Preguntas frecuentes

Podophyllum resin is a complex mixture of cytotoxic compounds extracted from the Podophyllum plant species, with podophyllotoxin as the principal active constituent, that exerts antimitotic effects by binding to tubulin and inhibiting microtubule polymerization, arresting cell division in metaphase. It has been used topically as a caustic agent for the treatment of condylomata acuminata and other warts.

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Yes, Podophyllum Resin is an approved drug. It has reached clinical phase 4. It is classified as a Unknown.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

  • ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2108775. Open-access bioactivity database.
  • PubChem — National Center for Biotechnology Information (NCBI). CID 11979494. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.