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Pyridostigmine

CHEMBL1115 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
181.2 g/mol
LogP
0.7
Phase
4

Pyridostigmine is a reversible acetylcholinesterase inhibitor of the carbamate class that prevents the hydrolysis of acetylcholine at cholinergic synapses, increasing the concentration and duration of action of acetylcholine at the neuromuscular junction and parasympathetic effector organs. It is primarily used for the symptomatic treatment of myasthenia gravis and has also been investigated as a pretreatment against nerve agent exposure.

Peso molecular

181,2100 g/mol

LogP

0,70

TPSA

33,40 Ų

Regla de cinco de Lipinski

Cumple

Áreas terapéuticas

Cáncer de pulmón de células no pequeñas Enfermedad de Parkinson Hiperplasia prostática benigna Insuficiencia cardíaca Leucemia VIH/sida

Mecanismo de acción

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN(C)C(=O)Oc1ccc[n+](C)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H13N2O2+

                    

                    
                    

                        
HBD / HBA

                        
- / 2

                    

                    
                    

                        
Enlaces Rotables

                        
2

                    

                    
                    
                    

                        
Átomos Pesados

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
Pyridostigmine is a reversible acetylcholinesterase inhibitor of the carbamate class that prevents the hydrolysis of acetylcholine at cholinergic synapses, increasing the concentration and duration of action of acetylcholine at the neuromuscular junction and parasympathetic effector organs. It is primarily used for the symptomatic treatment of myasthenia gravis and has also been investigated as a pretreatment against nerve agent exposure.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Pyridostigmine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1115.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4991.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.