Riociguat
Riociguat is a soluble guanylate cyclase (sGC) stimulator that acts by two distinct mechanisms: sensitizing sGC to endogenous nitric oxide (NO) and directly stimulating sGC independently of NO, thereby increasing cyclic GMP production in vascular smooth muscle and causing vasodilation and antiproliferative effects. It is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Peso molecular
422,4000 g/mol
LogP
1,60
TPSA
138,00 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
COC(=O)N(C)c1c(N)nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N
InChI
InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
Molecular Formula
C20H19FN8O2
HBD / HBA
2 / 9
Enlaces Rotables
5
Átomos Pesados
31
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Riociguat is a soluble guanylate cyclase (sGC) stimulator that acts by two distinct mechanisms: sensitizing sGC to endogenous nitric oxide (NO) and directly stimulating sGC independently of NO, thereby increasing cyclic GMP production in vascular smooth muscle and causing vasodilation and antiproliferative effects. It is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Yes, Riociguat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2107834. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11304743. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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