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Tolazoline Hydrochloride

CHEMBL1689 Phase 4 Aprobado Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
196.7 g/mol
LogP
—
Phase
4

Tolazoline hydrochloride is the hydrochloride salt form of tolazoline, an alpha-adrenergic antagonist and vasodilator previously used for pulmonary hypertension in neonates. See tolazoline for complete pharmacological details. This salt form was used in intravenous preparations for treatment of persistent pulmonary hypertension.

Peso molecular

196,6700 g/mol

TPSA

24,40 Ų

Mecanismo de acción

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mecanismo

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Estructura 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cl.c1ccc(CC2=NCCN2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H13ClN2

                    

                    
                    

                        
HBD / HBA

                        
2 / 1

                    

                    
                    

                        
Enlaces Rotables

                        
2

                    

                    
                    
                    

                        
Átomos Pesados

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Preguntas frecuentes

                

                    
                    

                        
                        

                            
Tolazoline hydrochloride is the hydrochloride salt form of tolazoline, an alpha-adrenergic antagonist and vasodilator previously used for pulmonary hypertension in neonates. See tolazoline for complete pharmacological details. This salt form was used in intravenous preparations for treatment of persistent pulmonary hypertension.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tolazoline Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1689.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6048.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Aviso médico

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.