Trilostane
Trilostane is a synthetic steroid analog that inhibits 3-beta-hydroxysteroid dehydrogenase, an enzyme critical for adrenal steroidogenesis, thereby reducing production of cortisol, aldosterone, and other steroids. It is used primarily in veterinary medicine to treat hyperadrenocorticism (Cushing's disease) and has been investigated in humans for adrenal-dependent conditions including certain hormone-sensitive cancers. Its adrenosuppressive action makes it relevant in prostate cancer research due to androgen pathway interference.
Peso molecular
329,4000 g/mol
LogP
2,90
TPSA
76,80 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
C[C@]12CC[C@H]3[C@@H](CC[C@@]45O[C@@H]4C(O)=C(C#N)C[C@]35C)[C@@H]1CC[C@@H]2O
InChI
InChI=1S/C20H27NO3/c1-18-7-6-14-12(13(18)3-4-15(18)22)5-8-20-17(24-20)16(23)11(10-21)9-19(14,20)2/h12-15,17,22-23H,3-9H2,1-2H3/t12-,13-,14-,15-,17+,18-,19+,20+/m0/s1
Molecular Formula
C20H27NO3
HBD / HBA
2 / 4
Enlaces Rotables
0
Átomos Pesados
24
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Trilostane is a synthetic steroid analog that inhibits 3-beta-hydroxysteroid dehydrogenase, an enzyme critical for adrenal steroidogenesis, thereby reducing production of cortisol, aldosterone, and other steroids. It is used primarily in veterinary medicine to treat hyperadrenocorticism (Cushing's disease) and has been investigated in humans for adrenal-dependent conditions including certain hormone-sensitive cancers. Its adrenosuppressive action makes it relevant in prostate cancer research due to androgen pathway interference.
Yes, Trilostane is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200907. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 656583. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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