Triprolidine
Triprolidine is a first-generation H1 antihistamine of the pyrrolidine class that competitively blocks histamine receptors to relieve symptoms of allergic rhinitis, urticaria, and the common cold. It produces moderate sedation and anticholinergic effects due to CNS penetration. It is commonly found in combination over-the-counter products with decongestants for symptomatic cold and allergy relief.
Peso molecular
278,4000 g/mol
LogP
3,90
TPSA
16,10 Ų
Regla de cinco de Lipinski
Cumple
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1
InChI
InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+
Molecular Formula
C19H22N2
HBD / HBA
- / 2
Enlaces Rotables
4
Átomos Pesados
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Triprolidine is a first-generation H1 antihistamine of the pyrrolidine class that competitively blocks histamine receptors to relieve symptoms of allergic rhinitis, urticaria, and the common cold. It produces moderate sedation and anticholinergic effects due to CNS penetration. It is commonly found in combination over-the-counter products with decongestants for symptomatic cold and allergy relief.
Yes, Triprolidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL855. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5282443. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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