Vildagliptin
Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the enzymatic degradation of incretin hormones GLP-1 and GIP, prolonging their physiological effects of glucose-dependent insulin secretion stimulation and glucagon suppression to improve glycemic control in type 2 diabetes. It is used as monotherapy or in combination with metformin, sulfonylureas, or insulin for type 2 diabetes management. DPP-4 inhibition provides glucose-dependent hypoglycemic effects with low risk of hypoglycemia.
Peso molecular
303,4000 g/mol
LogP
0,90
TPSA
76,40 Ų
Regla de cinco de Lipinski
Cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
N#C[C@@H]1CCCN1C(=O)CNC12CC3CC(CC(O)(C3)C1)C2
InChI
InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
Molecular Formula
C17H25N3O2
HBD / HBA
2 / 4
Enlaces Rotables
3
Átomos Pesados
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that prevents the enzymatic degradation of incretin hormones GLP-1 and GIP, prolonging their physiological effects of glucose-dependent insulin secretion stimulation and glucagon suppression to improve glycemic control in type 2 diabetes. It is used as monotherapy or in combination with metformin, sulfonylureas, or insulin for type 2 diabetes management. DPP-4 inhibition provides glucose-dependent hypoglycemic effects with low risk of hypoglycemia.
Yes, Vildagliptin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL142703. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6918537. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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