Vincristine
This plant-derived chemotherapy medication disrupts the formation of the mitotic spindle that cancer cells need to divide, and is a mainstay of treatment for leukemia, lymphoma, and certain pediatric solid tumors. It is given intravenously and is notable for causing peripheral neuropathy — numbness, tingling, and weakness in the hands and feet — as its main dose-limiting side effect. Accidental administration into the spinal canal (intrathecal) is invariably fatal, so strict safety protocols are in place.
Peso molecular
825,0000 g/mol
LogP
2,80
TPSA
171,00 Ų
Regla de cinco de Lipinski
No cumple
Áreas terapéuticas
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Estructura 2D
Cite this structure
Embed this structure
SMILES
CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1
InChI
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
Molecular Formula
C46H56N4O10
HBD / HBA
3 / 12
Enlaces Rotables
10
Átomos Pesados
60
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Preguntas frecuentes
This plant-derived chemotherapy medication disrupts the formation of the mitotic spindle that cancer cells need to divide, and is a mainstay of treatment for leukemia, lymphoma, and certain pediatric solid tumors. It is given intravenously and is notable for causing peripheral neuropathy — numbness, tingling, and weakness in the hands and feet — as its main dose-limiting side effect. Accidental administration into the spinal canal (intrathecal) is invariably fatal, so strict safety protocols are in place.
Yes, Vincristine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL90555. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5978. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="vincristine"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/vincristine/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/vincristine/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/vincristine/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="vincristine"></drugfyi-drug>