Descripción

Diphenhydramine adds to the sedative effects of alprazolam, increasing the risk of excessive CNS depression, falls, and cognitive impairment.

Mecanismo

Diphenhydramine's CNS depressant effect (H1 blockade + anticholinergic) is additive to benzodiazepine-mediated GABA-A potentiation.

Relevancia clínica

Particularly dangerous in elderly patients (Beers Criteria lists both drugs as potentially inappropriate); significantly raises fall risk.

Manejo clínico

Avoid combination in elderly patients; use non-sedating alternatives and consider dose reduction if both are required.

Aviso médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.