Major
Established
Descripción
Concurrent use of diazepam and oxycodone dramatically increases the risk of fatal respiratory depression, per FDA boxed warning.
Mecanismo
Additive CNS depression via GABA-A (diazepam) and mu-opioid receptor (oxycodone) pathways; concurrent use reduces hypoxic ventilatory response.
Relevancia clínica
Patients receiving both agents show substantially higher rates of emergency department visits and overdose deaths.
Manejo clínico
Avoid combination or use the lowest possible doses for the shortest duration; co-prescribe naloxone and educate patients.