Major
Established
Descripción
Diazepam and zolpidem together produce compounded GABA-A-mediated CNS depression, with risk of severe sedation and respiratory compromise.
Mecanismo
Additive enhancement of GABA-A inhibitory neurotransmission; diazepam has longer duration of action which prolongs the interaction window.
Relevancia clínica
Excess sedation, anterograde amnesia, and impaired psychomotor function are reliably increased with dual GABA-A modulator use.
Manejo clínico
Avoid combination; if a hypnotic is needed during benzodiazepine therapy, optimize the benzodiazepine regimen first.