Major
Probable
Descripción
Quetiapine substantially potentiates oxycodone-induced CNS and respiratory depression, and both drugs prolong the QT interval.
Mecanismo
Quetiapine's CNS depressant and QT-prolonging properties combine with oxycodone's opioid-receptor-mediated CNS and respiratory depression.
Relevancia clínica
The combination is implicated in multiple fatal overdose cases and carries dual CNS depression and arrhythmia risk.
Manejo clínico
Avoid combination; if unavoidable, use minimum effective doses, monitor ECG and respiratory status, and prescribe naloxone.