Acetaminophen vs Hydrochlorothiazide

## Acetaminophen vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Acetaminophen** and **Hydrochlorothiazide**.

## Mechanism of Action

**Acetaminophen**: Inhibits prostaglandin synthesis in the CNS and peripherally blocks pain impulse generation.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Acetaminophen — 1-4 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Acetaminophen — C8H9NO2; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Acetaminophen — 151.1630 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Acetaminophen — Small molecule; Hydrochlorothiazide — Small molecule.