Afatinib vs Erlotinib

## Afatinib vs Erlotinib: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Erlotinib**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Erlotinib**: Reversible inhibitor of EGFR (HER1) tyrosine kinase, blocking autophosphorylation.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Erlotinib — 36 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Erlotinib — C22H23N3O4.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Erlotinib — 393.4380 g/mol.

**Type**: Afatinib — Small molecule; Erlotinib — Small molecule.