Afatinib vs Tofacitinib

## Afatinib vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Afatinib** and **Tofacitinib**.

## Mechanism of Action

**Afatinib**: Irreversible covalent inhibitor of ErbB family (EGFR/HER1, HER2, HER4) tyrosine kinases.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Afatinib — 37 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Afatinib — C24H25ClFN5O3; Tofacitinib — C16H20N6O.

**Molecular Weight**: Afatinib — 485.9400 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Afatinib — Small molecule; Tofacitinib — Small molecule.