Atezolizumab vs Ipilimumab

## Atezolizumab vs Ipilimumab: Overview

This comparison examines the pharmacological differences between **Atezolizumab** and **Ipilimumab**.

## Mechanism of Action

**Atezolizumab**: Fully human anti-PD-L1 IgG1 monoclonal antibody blocking PD-L1 interaction with PD-1 and B7.1.

**Ipilimumab**: Fully human anti-CTLA-4 IgG1 monoclonal antibody that blocks CTLA-4 inhibitory signaling.

## Pharmacokinetics

**Half-life**: Atezolizumab — 27 days; Ipilimumab — 14.7 days.

## Chemical Properties

**Type**: Atezolizumab — Antibody; Ipilimumab — Antibody.