Captopril vs Diphenhydramine

## Captopril vs Diphenhydramine: Overview

This comparison examines the pharmacological differences between **Captopril** and **Diphenhydramine**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Diphenhydramine — 2-8 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Diphenhydramine — C17H21NO.

**Molecular Weight**: Captopril — 217.2850 g/mol; Diphenhydramine — 255.3550 g/mol.

**Type**: Captopril — Small molecule; Diphenhydramine — Small molecule.