Clonazepam vs Lorazepam

## Clonazepam vs Lorazepam: Overview

This comparison examines the pharmacological differences between **Clonazepam** and **Lorazepam**.

## Mechanism of Action

**Clonazepam**: Long-acting benzodiazepine positive allosteric modulator of GABA-A receptors.

**Lorazepam**: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

## Pharmacokinetics

**Half-life**: Clonazepam — 30-40 hours; Lorazepam — 10-20 hours.

## Chemical Properties

**Molecular Formula**: Clonazepam — C15H10ClN3O3; Lorazepam — C15H10Cl2N2O2.

**Molecular Weight**: Clonazepam — 315.7150 g/mol; Lorazepam — 321.1580 g/mol.

**Type**: Clonazepam — Small molecule; Lorazepam — Small molecule.