Diphenhydramine vs Memantine

## Diphenhydramine vs Memantine: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Memantine**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Memantine**: Non-competitive NMDA receptor antagonist.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Memantine — 60-80 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Memantine — C12H21N.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Memantine — 179.3080 g/mol.

**Type**: Diphenhydramine — Small molecule; Memantine — Small molecule.