Hydrochlorothiazide vs Trimethoprim

## Hydrochlorothiazide vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Trimethoprim**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Trimethoprim — Small molecule.