Loratadine vs Sildenafil

## Loratadine vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Sildenafil**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Loratadine — Small molecule; Sildenafil — Small molecule.