Lovastatin vs Pravastatin

## Lovastatin vs Pravastatin: Overview

This comparison examines the pharmacological differences between **Lovastatin** and **Pravastatin**.

## Mechanism of Action

**Lovastatin**: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

**Pravastatin**: Competitive inhibitor of HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Lovastatin — 2-3 hours; Pravastatin — 1.8 hours.

## Chemical Properties

**Molecular Formula**: Lovastatin — C24H36O5; Pravastatin — C23H36O7.

**Molecular Weight**: Lovastatin — 404.5390 g/mol; Pravastatin — 424.5280 g/mol.

**Type**: Lovastatin — Small molecule; Pravastatin — Small molecule.