Metformin vs Sildenafil

## Metformin vs Sildenafil: Overview

This comparison examines the pharmacological differences between **Metformin** and **Sildenafil**.

## Mechanism of Action

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

**Sildenafil**: Selective PDE5 inhibitor increasing cGMP.

## Pharmacokinetics

**Half-life**: Metformin — 4-9 hours; Sildenafil — 4 hours.

## Chemical Properties

**Molecular Formula**: Metformin — C4H11N5; Sildenafil — C22H30N6O4S.

**Molecular Weight**: Metformin — 129.1640 g/mol; Sildenafil — 474.5800 g/mol.

**Type**: Metformin — Small molecule; Sildenafil — Small molecule.