Methotrexate vs Spironolactone

## Methotrexate vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Methotrexate** and **Spironolactone**.

## Mechanism of Action

**Methotrexate**: Dihydrofolate reductase inhibitor.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Methotrexate — 3-10 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Methotrexate — C20H22N8O5; Spironolactone — C24H32O4S.

**Molecular Weight**: Methotrexate — 454.4400 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Methotrexate — Small molecule; Spironolactone — Small molecule.