Methylprednisolone vs Tacrolimus

## Methylprednisolone vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Methylprednisolone** and **Tacrolimus**.

## Mechanism of Action

**Methylprednisolone**: Intermediate-acting synthetic glucocorticoid.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Methylprednisolone — 18-36 hours; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Methylprednisolone — C22H30O5; Tacrolimus — C44H69NO12.

**Molecular Weight**: Methylprednisolone — 374.4710 g/mol; Tacrolimus — 804.0180 g/mol.

**Type**: Methylprednisolone — Small molecule; Tacrolimus — Small molecule.