Alclometasone Dipropionate
A low-potency topical corticosteroid used to reduce skin inflammation, redness, and itching associated with conditions such as psoriasis, eczema, and contact dermatitis. It works by suppressing inflammatory pathways in skin cells and is generally considered suitable for use on sensitive skin areas and in children due to its milder potency.
Masse moléculaire
521,0000 g/mol
LogP
3,20
TPSA
107,00 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Structure 2D
Cite this structure
Embed this structure
SMILES
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@H]2[C@H]3[C@H]([C@@H](O)C[C@@]21C)[C@@]1(C)C=CC(=O)C=C1C[C@H]3Cl
InChI
InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1
Molecular Formula
C28H37ClO7
HBD / HBA
1 / 7
Liaisons Rotatives
8
Atomes Lourds
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A low-potency topical corticosteroid used to reduce skin inflammation, redness, and itching associated with conditions such as psoriasis, eczema, and contact dermatitis. It works by suppressing inflammatory pathways in skin cells and is generally considered suitable for use on sensitive skin areas and in children due to its milder potency.
Binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene transcription. This suppresses multiple inflammatory genes encoding cytokines, chemokines, and adhesion molecules while inducing anti-inflammatory proteins.
Yes, Alclometasone Dipropionate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200989. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 636374. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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