Atazanavir
A protease inhibitor that prevents HIV from maturing into infectious viral particles by blocking the protease enzyme the virus needs to assemble itself. It is taken once daily as part of combination antiretroviral therapy.
Masse moléculaire
704,9000 g/mol
LogP
5,60
TPSA
171,00 Ų
Règle des 5 de Lipinski
Non conforme
Aires thérapeutiques
Mécanisme d'action
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Structure 2D
Cite this structure
Embed this structure
SMILES
COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C
InChI
InChI=1S/C38H52N6O7/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)/t29-,30-,31+,32+/m0/s1
Molecular Formula
C38H52N6O7
HBD / HBA
5 / 9
Liaisons Rotatives
18
Atomes Lourds
51
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A protease inhibitor that prevents HIV from maturing into infectious viral particles by blocking the protease enzyme the virus needs to assemble itself. It is taken once daily as part of combination antiretroviral therapy.
Inhibits viral protease, an enzyme essential for cleaving polyprotein precursors into functional viral proteins required for viral maturation and infectivity.
Yes, Atazanavir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1163. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 148192. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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