Azelastine
A second-generation antihistamine available as a nasal spray or eye drops that blocks H1 receptors locally to relieve nasal allergy symptoms and allergic conjunctivitis with minimal systemic sedation.
Masse moléculaire
381,9000 g/mol
LogP
4,40
TPSA
35,90 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Structure 2D
Cite this structure
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SMILES
CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1
InChI
InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
Molecular Formula
C22H24ClN3O
HBD / HBA
- / 3
Liaisons Rotatives
3
Atomes Lourds
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A second-generation antihistamine available as a nasal spray or eye drops that blocks H1 receptors locally to relieve nasal allergy symptoms and allergic conjunctivitis with minimal systemic sedation.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Azelastine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL639. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2267. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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