Baclofen
A GABA-B receptor agonist that inhibits the release of excitatory neurotransmitters in the spinal cord, reducing muscle spasms and rigidity in conditions such as multiple sclerosis and spinal cord injury. It is also studied for alcohol use disorder.
Masse moléculaire
213,6600 g/mol
LogP
-1,00
TPSA
63,30 Ų
Règle des 5 de Lipinski
Conforme
Aires thérapeutiques
Mécanisme d'action
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Structure 2D
Cite this structure
Embed this structure
SMILES
NCC(CC(=O)O)c1ccc(Cl)cc1
InChI
InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
Molecular Formula
C10H12ClNO2
HBD / HBA
2 / 3
Liaisons Rotatives
4
Atomes Lourds
14
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Foire aux questions
A GABA-B receptor agonist that inhibits the release of excitatory neurotransmitters in the spinal cord, reducing muscle spasms and rigidity in conditions such as multiple sclerosis and spinal cord injury. It is also studied for alcohol use disorder.
Binds to and activates its target receptor, mimicking the action of the endogenous ligand to produce a specific physiological response.
Yes, Baclofen is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL701. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2284. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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